Simbios Talk by David Parker, Stanford University, December 3, 2008

Title: Coarse-grained Modeling of Myosin V Dynamics

Myosin V is a two-headed motor protein that moves along single actin filaments transporting cellular cargoes within the cytoplasm. I have constructed three-dimensional all-atom models of a myosin V dimer attached to actin in order to investigate the structure-function relationships that underlie its directed movement along actin. I will also discuss the software system I have developed for creating and simulating coarse-grained models of motor proteins.